We hypothesize that lncRNA HNF1A-AS1 relieves the inhibition of downstream target genes by competitively binding to miR-124, thereby inhibiting cellular ferroptosis.

The lactate‐induced lactylation of histone lysine residues bridges the metabolic reprogramming and epigenetic rewiring. Histone lactylation fuels oncogene overexpression, expediting tumour progression and development. Targeting lactate signalling exhibits with therapeutic efficacy in diversified cancers. 1. INTRODUCTION In the past, lactate was primarily regarded as an outcome of energy ...

On the basis of competitive endogenous RNAs (ceRNAs) system, lncRNAs significantly expanded their regulating networks. In our research, we aimed to figure out the exact role of lncRNA HNF1A-AS1 in the pathogenesis of hepatocellular carcinoma (HCC), in a ceRNA-dependent way.

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